Bafilomycin A1

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Chemical Information

Product name：Bafilomycin A1	Purity：98% min
CAS NO：88899-55-2	Solubility：DMSO : 100 mg/mL (160.56 mM)
Molecular Formula：C₃₅H₅₈O₉	Package：Package according to customer requirements
Molecular Weight：622.830	Storage：Store at -20℃

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Remarks

Bafilomycin A1, also known as NSC 381866, is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways.

Proton Pump Inhibitors Related Products:

PF-03716556; Lansoprazole; Dexlansoprazole; Rebeprazole sodium

References

[1]. Yuan N, et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56.

[2]. Lu X, et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2015 Nov;10(5):1829-1834.