PF-03716556

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：PF-03716556	Purity：98% min
CAS NO：928774-43-0	Solubility：DMSO : 23 mg/mL (58.31 mM)
Molecular Formula：C₂₂H₂₆N₄O₃	Package：Package according to customer requirements
Molecular Weight：394.475	Storage：Store at -20℃

Quality control

Remarks

PF-03716556 is a potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. PF-03716556 demonstrated 3-fold greater inhibitory activity than revaprazan. PF-03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney Na(+),K(+)-ATPase. Kinetics experiments revealed that PF-03716556 has a competitive and reversible mode of action.

Proton Pump Inhibitors Related Products:

Lansoprazole; Dexlansoprazole; Rebeprazole sodium; Bafilomycin A1

References

[1]. Mori et al (2009) N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]py ridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease