SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
Chemical Properties:
density: 1.53±0.1 g/cm3(Predicted)
pka: 8.87±0.43(Predicted)
P-gp inhibitor Related Prodcuts:
Zosuquidar trihydrochloride; Elacridar; Tariquidar