SNS-314

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Chemical Information

Product name：SNS-314	Purity：98% min
CAS NO：1057249-41-8	Solubility：DMSO : 50 mg/mL (94.87 mM)
Molecular Formula：C₁₉H₁₉ClN₆O₄S₃	Package：Package according to customer requirements
Molecular Weight：527.040	Storage：Store at -20℃

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Remarks

SNS-314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.

Related Products:

SRT1720 hcl; Barasertib; ABT-751; MK-5108; SNS-314 mesylate; Alisertib; Abexinostat; Romidepsin; R547; Tubastatin A HCL; SCH900776; PF00477736; GW7647; Dalcetrapib

References

[1]. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4.

[2]. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.