MK-8776 SCH900776

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Chemical Information

Product name：MK-8776 SCH900776	Purity：98% min
CAS NO：891494-63-6	Solubility：DMSO : ≥ 100 mg/mL (265.78 mM)
Molecular Formula：C₁₅H₁₈BrN₇	Package：Package according to customer requirements
Molecular Weight：376.254	Storage：Store at -20℃

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Remarks

SCH900776, also known as MK-8776. is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor SCH 900776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents.

Related Products:

SRT1720 hcl; Barasertib; ABT-751; MK-5108; SNS-314; SNS-314 mesylate; Alisertib; Abexinostat; Romidepsin; R547; Tubastatin A HCL; PF00477736; GW7647; Dalcetrapib

References

[1]. Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38.

[2]. Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.