Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.
Properties:
Appearance & Physical State: white to off-white crystalline powder
Density: 1.233 g/cm3
Boiling Point: 606.3ºC at 760 mmHg
Melting Point: 319-322ºC
Flash Point: 205.9ºC
Refractive Index: 1.654
Vapor Pressure: 1.49E-15mmHg at 25°C
Retinoid Receptor inhibitor Related Products:
Fenretinide; Retinoic acid; Acitretin; Tazarotene; Tamibarotene; AM580; Bexarotene