Bexarotene

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Chemical Information

Product name：Bexarotene	Purity：98% min
CAS NO：153559-49-0	Solubility：DMSO : 60 mg/mL (172.18 mM)
Molecular Formula：C₂₄H₂₈O₂	Package：Package according to customer requirements
Molecular Weight：348.478	Storage：Store at -20℃

Quality control

COA

Remarks

Bexarotene, also known as LGD-1069, is a synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression.

Retinoid Receptor inhibitor Related Products:

Fenretinide; Retinoic acid; Adapalene; Acitretin; Tazarotene; Tamibarotene; AM580

References

[1]. Vakeva L, Ranki A, Hahtola S. Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland. Acta Derm Venereol. 2012 May;92(3):258-63. doi: 10.2340/00015555-1359.

[2]. Zhang X, Schlaak M, Fabri M, Mauch C, Kurschat P. Successful Treatment of a Panniculitis-Like Primary Cutaneous T-Cell Lymphoma of the α/β Type with Bexarotene. Case Rep Dermatol. 2012 Jan;4(1):56-60.