Tretinoin Retinoic acid

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Chemical Information

Product name：Tretinoin Retinoic acid	Purity：99% min
CAS NO：302-79-4	Solubility：DMSO : ≥ 50 mg/mL (166.42 mM)
Molecular Formula：C₂₀H₂₈O₂	Package：Package according to customer requirements
Molecular Weight：300.435	Storage：Store at -20℃

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Remarks

Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM.

Properties:
Appearance & Physical State: Yellow-orange powder
Density: 1.011 g/cm3
Boiling Point: 462.8ºC at 760 mmHg
Melting Point: 179-184ºC
Flash Point: 350.6ºC

Retinoid Receptor inhibitor Related Products:

Fenretinide; Adapalene; Acitretin; Tazarotene; Tamibarotene; AM580; Bexarotene

References

[1]. Wu L, et al. Retinoid X Receptor Agonists Upregulate Genes Responsible for the Biosynthesis of All-Trans-Retinoic Acid in Human Epidermis. PLoS One. 2016 Apr 14;11(4):e0153556.

[2]. Shaw N, et al. Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta/delta. J Biol Chem. 2003 Oct 24;278(43):41589-92.