Defactinib VS-6063

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Chemical Information

Product name：Defactinib VS-6063	Purity：98% min
CAS NO：1073154-85-4	Solubility：DMSO : ≥ 39 mg/mL (76.40 mM)
Molecular Formula：C₂₀H₂₁F₃N₈O₃S	Package：Package according to customer requirements
Molecular Weight：510.49	Storage：Store at -20℃

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Remarks

Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.

FAK Inhibitors Related Products:

PND-1186; Defactinib hydrochloride; PF-00562271; PF-431396; PF-00562271 Besylate; PF-573228

References

[1]. Kang Y, et al. Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95.