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Product :

Defactinib hydrochloride

Defactinib hydrochloride 1073160-26-5
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Chemical Information
Product name:Defactinib hydrochloride Purity:98% min
CAS NO:1073160-26-5 Solubility:DMSO : 30 mg/mL (54.85 mM)
Molecular Formula:C20H22ClF3N8O3S Package:Package according to customer requirements
Molecular Weight:546.954 Storage:Store at -20℃
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Remarks

Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.

Defactinib hydrochloride is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 

 

 

 

FAK Inhibitors Related Products:

PND-1186; Defactinib; PF-00562271; PF-431396; PF-00562271 Besylate; PF-573228 

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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