PF-00562271 Besylate

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Chemical Information

Product name：PF-00562271 Besylate	Purity：98% min
CAS NO：939791-38-5	Solubility：DMSO : 21.4 mg/mL (32.15 mM)
Molecular Formula：C₂₇H₂₆F₃N₇O₆S₂	Package：Package according to customer requirements.
Molecular Weight：665.664	Storage：Store at -20℃

Quality control

COA

Remarks

PF-562271 Besylate, also known as PF-562,271 and PF-271, is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF-562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. Note: PF-562271 benzesulfonate is also called PF-562271 besylate.

FAK Inhibitors Related Products:

PND-1186; Defactinib hydrochloride; Defactinib; PF-00562271; PF-431396; Defactinib

References

[1]. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.

[2]. Lim ST, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7(15), 2306-2314.

[3]. Canel M, et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res, 2010, 70(22), 9413-9422.