PF-00562271

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Chemical Information

Product name：PF-00562271	Purity：98% min
CAS NO：717907-75-0	Solubility：DMSO : ≥ 48 mg/mL (94.58 mM)
Molecular Formula：C₂₁H₂₀F₃N₇O₃S	Package：Package according to customer requirements
Molecular Weight：507.489	Storage： Store at -20℃

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Remarks

PF-562271, also known as PF-562,271 and PF-271, is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF-562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival.

FAK Inhibitors Related Products:

PND-1186; Defactinib hydrochloride; Defactinib; PF-431396; PF-00562271 Besylate; PF-573228

References

[1]. Roberts WG, et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res, 2008, 68(6), 1935-1944.

[2]. Crompton BD, et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83.