KOM70144 PLpro inhibitor

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Chemical Information

Product name：KOM70144 PLpro inhibitor	Purity：98% min
CAS NO：1093070-14-4	Solubility：DMSO : ≥ 42 mg/mL (121.24 mM)
Molecular Formula：C₂₂H₂₂N₂O₂	Package：Package according to customer requirements.
Molecular Weight：346.422	Storage：-20 ℃

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Remarks

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM.

Synonyms:

5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide;

I06-1404;

5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide;

PLpro inhibitor;

5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide;

SARS-CoV Inhibitors Related Products:

Nafamostat; Nafamostat mesylate; PF-07321332; PF-00835231; ML188; Molnupiravir N-1; Molnupiravir

References

[1]. Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.

[2]. http://www.google.com/patents/WO2010022355A1cl=en