Nafamostat

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Chemical Information

Product name：Nafamostat	Purity：99% min
CAS NO：81525-10-2	Solubility：Soluble in DMSO
Molecular Formula：C₁₉H₁₇N₅O₂	Package：Package according to customer requirements
Molecular Weight：347.371	Storage：Store at -20℃

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Remarks

Nafamostat, also known as FUT-175, is a serine protease inhibitor and an anticoagulant. Nafamostat promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat protects against acute cerebral ischemia via blood-brain barrier protection. Nafamostat Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production.

Properties:
Density: 1.39g/cm3
Boiling Point: 637.2ºC at 760 mmHg
Flash Point: 339.1ºC
Refractive: Index 1.694

Serine Protease Inhibitors Related Products:

Aprotinin; Alvelestat; Leupeptin hemisulfate; Nafamostat mesylate; PMSF; AEBSF hydrochloride

References

[1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.

[2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.