Nafamostat mesylate

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Chemical Information

Product name：Nafamostat mesylate	Purity：99% min
CAS NO：82956-11-4	Solubility：DMSO : 50 mg/mL (92.66 mM)
Molecular Formula：C₂₀H₂₁N₅O₅S	Package：Package according to customer requirements
Molecular Weight：443.476	Storage：Store at -20℃

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Remarks

Nafamostat, also known as FUT-175, is a serine protease inhibitor and an anticoagulant. Nafamostat promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat protects against acute cerebral ischemia via blood-brain barrier protection. Nafamostat Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production.

Nafamostat mesylate, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat mesylate supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat mesylate blocks activation of SARS-CoV-2..

Serine Protease Inhibitors Related Products:

Aprotinin; Alvelestat; Leupeptin hemisulfate; Nafamostat; PMSF; AEBSF hydrochloride

References

[1]. Ikehara S, et al. Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice. Immunology. 1985 Aug;55(4):595-600.

[2]. Pak K, et al. Effectiveness of FUT-175, protease inhibitor, as an anticoagulant to hemodialysis. Hinyokika Kiyo. 1988 Jun;34(6):1077-81.