ML188

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Chemical Information

Product name：ML188	Purity：98% min
CAS NO：1417700-13-0	Solubility：DMSO : 250 mg/mL (576.65 mM)
Molecular Formula：C₂₆H₃₁N₃O₃	Package：Package according to customer requirements.
Molecular Weight：433.552	Storage：-20 ℃

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Remarks

ML188 is a Potent Noncovalent Small Molecule Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease. The X-ray structure of SARS-CoV 3CLpro bound with ML188 was instrumental in guiding subsequent rounds of chemistry optimization. ML188 provides an excellent starting point for the further design and refinement of 3CLpro inhibitors that act by a noncovalent mechanism of action.

SARS-CoV Inhibitors Related Products:

Nafamostat; Nafamostat mesylate; PF-07321332; PLpro inhibitor; PF-00835231; Molnupiravir N-1 ; Molnupiravir

References

[1]. Jacobs J, et al. Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24;56(2):534-46.