EMD-1214063 Tepotinib

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Chemical Information

Product name：EMD-1214063 Tepotinib	Purity：98% min
CAS NO：1100598-32-0	Solubility：DMSO : 27 mg/mL (54.81 mM)
Molecular Formula：C₂₉H₂₈N₆O₂	Package：Package according to customer requirements
Molecular Weight：492.572	Storage：Store at -20℃

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Remarks

Tepotinib, also known as EMD 1214063 and MSC2156119, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.

Related Products:

Capmatinib; MK-8033; Merestinib; SGX-523; MDK-0264; NPS-1034; WYE-125132; PHA-665752; SCR-1481B1; SU11606

References

[1]. Bladt F, et al. EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res, 2013, 19(11), 2941-2951.

[2]. Zhan N, et al. The Effect of Selective c-MET Inhibitor on Hepatocellular Carcinoma in the MET-Active, β-Catenin-Mutated Mouse Model. Gene Expr. 2018 May 18;18(2):135-147.