NPS-1034

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Chemical Information

Product name：NPS-1034	Purity：99% min
CAS NO：1221713-92-3	Solubility：DMSO : 34 mg/mL (61.65 mM)
Molecular Formula：C₃₁H₂₃F₂N₅O₃	Package：Package according to customer requirements
Molecular Weight：551.543	Storage：Store at -20℃

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Remarks

NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752.

Related Products:

Capmatinib; MK-8033; Merestinib; SGX-523; MDK-0264; Tepotinib; WYE-125132; PHA-665752; SCR-1481B1; SU11606

References

[1]. Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74(1):253-62.

[2]. Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99.