SU11606

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Chemical Information

Product name：SU11606	Purity：98% min
CAS NO：669764-17-4	Solubility：Soluble in DMSO
Molecular Formula：C₂₉H₃₃ClN₄O₄S	Package：Package according to customer requirements
Molecular Weight：569.11472	Storage：Store at -20℃

Quality control

Remarks

SU11606 is a potent c-MET inhibitor with potential anticancer activity.

IUPAC/Chemical Name: (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(3-morpholinopropyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide

InChi Key: JXOCDHNKTVLZLD-ITYLOYPMSA-N

InChi Code: InChI=1S/C29H33ClN4O4S/c1-19-24(8-5-11-34-12-14-38-15-13-34)20(2)31-28(19)18-26-25-17-23(9-10-27(25)32-29(26)35)39(36,37)33(3)22-7-4-6-21(30)16-22/h4,6-7,9-10,16-18,31H,5,8,11-15H2,1-3H3,(H,32,35)/b26-18-

SMILES Code: O=S(C1=CC2=C(NC(/C2=C\C3=C(C)C(CCCN4CCOCC4)=C(C)N3)=O)C=C1)(N(C5=CC=CC(Cl)=C5)C)=O

Related Products:

Capmatinib; MK-8033; Merestinib; SGX-523; MDK-0264; Tepotinib; NPS-1034; WYE-125132; PHA-665752; SCR-1481B1

References

1. Golub, Todd; Straussman, Ravid. Methods of treating cancer using a chemotherapeutic agent with an agent that blocks the activity of hepatocyte growth factor or its cognate receptor c-MET. From PCT Int. Appl. (2012), WO 2012178038 A1 20121227.

2. Smith, David; Hussain, Maha. Dual inhibitors of Met and VEGF for the treatment of castration resistant prostate cancer and osteoblastic bone metastases. PCT Int. Appl. (2012), WO 2012044577 A1 20120405