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WYE-125132

WYE-125132 1144068-46-1
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Chemical Information
Product name:WYE-125132 Purity:98% min
CAS NO:1144068-46-1 Solubility:DMSO: ≥ 150 mg/mL
Molecular Formula:C27H33N7O4 Package:Package according to customer requirements
Molecular Weight:375.399 Storage:Store at -20℃
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Remarks
WYE-125132, also known as WYE-132, is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC(50): 0.19 +/- 0.07 nmol/L; >5,000-fold selective versus PI3Ks). WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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