Ramatroban

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Chemical Information

Product name：Ramatroban	Purity：98% min
CAS NO：116649-85-5	Solubility：DMSO : 125 mg/mL (300.14 mM)
Molecular Formula：C₂₁H₂₁FN₂O₄S	Package：Package according to customer requirements
Molecular Weight：416.466	Storage：Store at -20℃

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Remarks

Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

Properties:
Appearance & Physical State: Crystalline solid.
Density: 1.43 g/cm3
Boiling Point: 654.7ºC at 760 mmHg
Flash Point: 349.7ºC
Refractive Index: 1.664
Stability: Stable at normal temperatures and pressures.
Vapor Pressure: 4.94E-18mmHg at 25°C

Prostaglandin Receptor Related Products:

E-7046; Ozagrel; Bimatoprost; Prostaglandin E2; Tafluprost; Carboprost; Treprostinil sodium; MRE-269; Travoprost; Misoprostol; Selexipag; Setipiprant

References

[1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D₂ receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.

[2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D₂-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.