E7046 is a potent and selective antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. E7046 has specific and potent inhibitory activity on PGE2-mediated pro-tumor myeloid cell differentiation and activation. E7046 treatment reduced the growth or even rejected established tumors in vivo in a manner dependent on both myeloid and CD8+ T cells.
Prostaglandin Receptor Related Products:
Ramatroban; Ozagrel; Bimatoprost; Prostaglandin E2; Tafluprost; Carboprost; Treprostinil sodium; MRE-269; Travoprost; Misoprostol; Selexipag; Setipiprant