Dorsomorphin 2HCl

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Chemical Information

Product name：Dorsomorphin 2HCl	Purity：98% min
CAS NO：1219168-18-9	Solubility：DMSO : 5.2 mg/mL (11.01 mM); H2O : ≥ 50 mg/mL (105.84 mM)
Molecular Formula：C₂₄H₂₇Cl₂N₅O	Package：Package according to customer requirements
Molecular Weight：472.41	Storage：Store at -20℃

Quality control

COA

Remarks

Dorsomorphin 2HCl (BML-275, Compound C) is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Also inhibits type Ⅰ BMP receptor activity. Dorsomorphin induces autophagy in cancer cell line.

AMPK Inhibitors Related Prodcuts:

Dorsomorphin (Compound C); WZ4003; ON123300; Doxorubicin HCl; GSK690693; MK-3903

References

[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.

[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.