Dorsomorphin compound C

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Chemical Information

Product name：Dorsomorphin compound C	Purity：98% min
CAS NO：866405-64-3	Solubility：DMSO : 5 mg/mL (12.52 mM)
Molecular Formula：C₂₄H₂₅N₅O	Package：Package according to customer requirements
Molecular Weight：399.488	Storage：Store at -20℃

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Remarks

Dorsomorphin, also known as BML-275 , is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.

AMPK Inhibitors Related Prodcuts:

Dorsomorphin 2HCl; WZ4003; ON123300; Doxorubicin HCl; GSK690693; MK-3903

References

[1]. Zhou G, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.

[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.

[3]. Yu PB, et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan;4(1):33-41.