TAK-063 Balipodect

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Chemical Information

Product name：TAK-063 Balipodect	Purity：98% min
CAS NO：1238697-26-1	Solubility：DMSO : 25 mg/mL (58.35 mM)
Molecular Formula：C₂₃H₁₇FN₆O₂	Package：Package according to customer requirements
Molecular Weight：428.418	Storage：Store at -20℃

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Remarks

TAK-063, also known as Balipodect., is a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. TAK-063 represents a promising drug for the treatment of schizophrenia with potential for superior safety and tolerability profiles.

PDE Inhibitors Related Products:

Roflumilast; Sildenafil citrate; Cilomilast; Tadalafil; Pimobendan; GSK256066; Mardepodect; Rolipram; Apremilast; Milrinone; Avanafil; Ziritaxestat; Ibudilast; PF8380; Deltarasin; Anagrelide hydrochloride; Enpp-1-IN-1; Crisaborole ; CP671305

References

[1]. Kunitomo J, et al. Discovery of 1-[2-Fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor. J Med Chem. 2014 Nov 26;57(22):9627-43.

[2]. Suzuki K, et al. In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents. J Pharmacol Exp Ther. 2014 Dec 18. pii: jpet.114.218552.