Rolipram

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Chemical Information

Product name：Rolipram	Purity：98% min
CAS NO：61413-54-5	Solubility：DMSO : ≥ 41 mg/mL (148.91 mM)
Molecular Formula：C₁₆H₂₁NO₃	Package：Package according to customer requirements
Molecular Weight：275.343	Storage：Store at -20℃

Quality control

Remarks

The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.

Properties:
Appearance & Physical State: solid
Density: 1.155 g/cm3
Melting Point: 127-133ºC
Boiling Point: 472.7ºC at 760 mmHg
Flash Point: 239.7ºC
Refractive Index: 1.552

PDE Inhibitors Related Products:

Roflumilast; Sildenafil citrate; Cilomilast; Tadalafil; Pimobendan; GSK256066; Mardepodect; Apremilast; Milrinone; Avanafil; Ziritaxestat; Ibudilast; Balipodect; PF8380; Deltarasin; Anagrelide hydrochloride; Enpp-1-IN-1; Crisaborole ; CP671305

References

[1]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr

[2]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.