Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
IC50 & Target:
Kd: 38 nM (PDEδ)
In Vitro:
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with Kd of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
In Vivo:
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.
PDE Inhibitors Related Products:
Roflumilast; Sildenafil citrate; Cilomilast; Tadalafil; Pimobendan; GSK256066; Mardepodect; Rolipram; Apremilast; Milrinone; Avanafil; Ziritaxestat; Ibudilast; Balipodect; PF8380; Anagrelide hydrochloride; Enpp-1-IN-1; Crisaborole; CP671305