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GSK256066 801312-28-7
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Chemical Information
Product name:GSK256066 Purity:98% min
CAS NO:801312-28-7 Solubility:DMSO : ≥ 5.2 mg/mL (10.03 mM)
Molecular Formula:C27H26N4O5S Package:Package according to customer requirements
Molecular Weight:518.584 Storage:Store at -20℃
Quality control
GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a protective effect on the EAR and LAR. GSK256066 is a slow and tight binding inhibitor of PDE4B (apparent IC(50) 3.2 pM; steady-state IC(50) <0.5 pM), which is more potent than any previously documented compound, for example, roflumilast (IC(50) 390 pM), tofimilast (IC(50) 1.6 nM), and cilomilast (IC(50) 74 nM). Consistent with this, GSK256066 inhibited tumor necrosis factor α production by lipopolysaccharide (LPS)-stimulated human peripheral blood monocytes with 0.01 nM IC(50). GSK256066 has been demonstrated to have exceptional potency in vitro and in vivo and is being clinically investigated as a treatment for chronic obstructive pulmonary disease.
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