BCI-215

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Chemical Information

Product name：BCI-215	Purity：99.0% min
CAS NO：1245792-67-9	Solubility：DMSO : 33.33 mg/mL (84.10 mM)
Molecular Formula：C₂₂H₂₂BrNO	Package：Package according to customer requirements
Molecular Weight：396.32	Storage：Store at -20℃

Quality control

Remarks

BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells.

Chemical Properties:

Boiling point: 523.0±50.0 °C(Predicted)

density: 1.37±0.1 g/cm3(Predicted)

pka: 6.32±0.20(Predicted)

Phosphatase Related Products:

KLH45; Voclosporin; Cyclosporin A; Tacrolimus; GSK 2830371; SF1670; L-p-Bromotetramisole oxalate; BTdCPU ; Salubrinal

References

[1]. Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.

[2]. Kaltenmeier CT, et al. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.