SF1670

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Chemical Information

Product name：SF1670	Purity：99% min
CAS NO：345630-40-2	Solubility：DMSO : ≥ 50 mg/mL (162.69 mM)
Molecular Formula：C₁₉H₁₇NO₃	Package：Packaging according to customer requirements
Molecular Weight：307.343	Storage：Store at 2-8°C

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Remarks

SF1670 is a specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor. SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM. The innate immune responses can be enhanced and the severity of neutropenia-related infection can be alleviated by augmenting phosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, providing a therapeutic strategy for improving the efficacy of granulocyte transfusion.

Chemical Properties:

Boiling point: 554.1±29.0 °C(Predicted)

density: 1.271±0.06 g/cm3(Predicted)

form: Red-violet solid

pka: 14.31±0.20(Predicted)

Phosphatase Related Products:

KLH45; Voclosporin; Cyclosporin A; Tacrolimus; GSK 2830371; BCI-215; L-p-Bromotetramisole oxalate; BTdCPU ; Salubrinal

References

[1]. Li Y, et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117(24):6702-13.

[2]. Montales MT, et al. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov;10(6):49.