Salubrinal

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal reduces oxidative stress, neuroinflammation and impulsive-like behavior in a rodent model of traumatic brain injury. Salubrinal protects human lens epithelial cells against endoplasmic reticulum stress-associated apoptosis. Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis.

Synonyms:

salubrinal;

F0095-1218;

eIF-2alpha Inhibitor,Salubrinal;

2-Propenamide (3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl];

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl] 2-propenamide;

Phosphatase Related Products:

KLH45; Voclosporin; Cyclosporin A; Tacrolimus; GSK 2830371; SF1670; BCI-215; L-p-Bromotetramisole oxalate; BTdCPU

[1]. Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4(1):e4161.

[2]. Hamamura K, et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27(4):828-35.