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CHR-6494

CHR-6494 1333377-65-3
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Chemical Information
Product name:CHR-6494 Purity:98% min
CAS NO:1333377-65-3 Solubility:DMSO : 50 mg/mL (171.03 mM)
Molecular Formula:C16H16N6 Package:Package according to customer requirements
Molecular Weight:292.338 Storage:Store at -20℃
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Remarks

CHR-6494 is a potent and selective histone kinase Haspin inhibitor. CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. CHR-6494 shows antitumor potential in xenografted nude mice without any observed toxicity. Thus, CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects that merits further preclinical research as a new member of the family of mitotic kinase inhibitors.

 

 

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