VX-680 Tozasertib

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Chemical Information

Product name：VX-680 Tozasertib	Purity：98% min
CAS NO：639089-54-6	Solubility：DMSO : ≥ 106.67 mg/mL (229.60 mM)
Molecular Formula：C₂₃H₂₈N₈OS	Package：Package according to customer requirements
Molecular Weight：464.586	Storage：Store at -20℃

Quality control

COA

Remarks

Tozasertib, also known as VX-680, MK0457 or VE465, is a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential for mitotic progression, spindle formation, centrosome maturation, chromosomal segregation, and cytokinesis.

Related Prodcuts:

Tenovin-1; CHR-6494; LDN-192960; Epothilone D; Cladribine; BI 2536; GW843682X; CYC-116; MK-1775; Entinostat

References

[1]. Harrington EA, et al. VX-680, a potent and selective smallmolecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 2004; 10:262-7.

[2]. Salah E, et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.J Med Chem. 2011 Apr 14;54(7):2359-67. Epub 2011 Mar 18.