Paliperidone

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Chemical Information

Product name：Paliperidone	Purity：98% min
CAS NO：144598-75-4	Solubility：DMSO : 5 mg/mL (11.72 mM)
Molecular Formula：C₂₃H₂₇FN₄O₃	Package：Package according to customer requirements.
Molecular Weight：426.484	Storage：Store at -20℃

Quality control

COA

Remarks

Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications. It is developed by Janssen Pharmaceutica. Invega is an extended release formulation of paliperidone that uses the OROS extended release system to allow for once-daily dosing.Paliperidone has antagonist effect at α1 and α2 adrenergic receptors and at H1 histamine receptors. It does not bind to muscarinic acetylcholine receptors. In addition, it binds with dopamine and serotonin receptors.

Dopamine Receptor Inhibitors Related Products:

Ropinirole hydrochloride; Quetiapine fumarate; Domperidone; Amisulpride; ONC206; Sulpiride ; SKF-38393 HCl

References

[1]. Peng L, et al. Paliperidone protects prefrontal cortical neurons from damages caused by MK-801 via Akt1/GSK3β signaling pathway. Schizophr Res. 2013 Jun;147(1):14-23.

[2]. Yang MC, et al. Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide(25-35), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology (Berl). 2011 Oct;217(3):397-410.