ONC206

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Chemical Information

Product name：ONC206	Purity：98% min
CAS NO：1638178-87-6	Solubility：DMSO : 100 mg/mL (244.83 mM)
Molecular Formula：C₂₃H₂₂F₂N₄O	Package：Package according to customer requirements
Molecular Weight：408.4528	Storage：-20℃

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Remarks

ONC206 is a chemical analogue of ONC201. ONC206 is a benzyl-flurobenzyl imipridone that has highly potent activity in preclinical models of difficult-to-treat neuroendocrine tumors and sarcomas. ONC206 acts as a selective antagonist of DRD2 at nanomolar concentrations and has broad-spectrum anti-tumor activity. ONC206 may address tumor types where the properties of ONC201 do not permit for complete therapeutic engagement in vivo.

Dopamine Receptor Inhibitors Related Products:

Ropinirole hydrochloride; Quetiapine fumarate; Domperidone; Paliperidone; Amisulpride; Sulpiride ; SKF-38393 HCl

References

[1]. Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799.

[2]. Varun Vijay Prabhu, et al. Potent anti-cancer activity of the imipridone ONC206: A selective dopamine D2-like receptor antagonist. AACR Annual Meeting 2017, April 1-5, 2017; Washington, DC.