2-D08

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Chemical Information

Product name：2-D08	Purity：98% min
CAS NO：144707-18-6	Solubility：DMSO : 150 mg/mL (555.06 mM)
Molecular Formula：C₁₅H₁₀O₅	Package：Package according to customer requirements
Molecular Weight：478.327	Storage：2-8°C

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Remarks

2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays.

Axl Inhibitors Related Products:

Cabozantinib; SGI-7079; BMS777607; Gilteritinib; Merestinib; Dubermatinib; NPS-1034; LDC1267; Bemcentinib

References

[1]. Kim YS, et al. Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an inhibitor of protein sumoylation. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.

[2]. Fujino N, et al. Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype. Lab Invest. 2017 Sep;97(9):1047-1062.