Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Sodium Channel Inhibitors Related Products:
Carbamazepine; A-803467; Camostat Mesilate; Ambroxol hcl; Proparacaine hydrochloride; Zonisamide; Zonisamide sodium salt; Dronedarone hcl; Baricitinib; Levobupivacaine; Levobupivacaine hcl; Vinpocetine; Propafenone hcl; Lamotrigine