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Cariporide 159138-80-4
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Chemical Information
Product name:Cariporide Purity:98% min
CAS NO:159138-80-4 Solubility:DMSO: ≥100 mg/mL
Molecular Formula:C12H17N3O3S Package:Package according to customer requirements
Molecular Weight:283.347 Storage:Store at -20℃
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Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na+ and Ca2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H2+O2+. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca2+ in cardiac myocytes through inhibition of Na+/H+ exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
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