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Sch66336 Lonafarnib

Sch66336 Lonafarnib 193275-84-2
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Chemical Information
Product name:Sch66336 Lonafarnib Purity:98% min
CAS NO:193275-84-2 Solubility:10 mM in DMSO
Molecular Formula:C27H31Br2ClN4O2 Package:Package according to customer requirements
Molecular Weight:638.822 Storage:Store at -20℃
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Remarks

Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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