A-922500 is a potent orally active inhibitor of DGAT-1 activity, inhibiting both human and mouse forms of the enzymes with IC50 values of 7 and 24 nM, respectively. Acyl CoA/diacylglycerol acyltransferase (DGAT) 1 is one of two known DGAT enzymes that catalyze the final and only committed step in triglyceride biosynthesis.
Transferase Inhibitors Related Products:
Tipifarnib; Lonafarnib; Daporinad; OSMI-1; PF-04620110; Ezatiostat; PF-9366