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PF-9366 72882-78-1
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Chemical Information
Product name:PF-9366 Purity:98% min
CAS NO:72882-78-1 Solubility:DMSO : 25 mg/mL (71.26 mM; Need ultrasonic)
Molecular Formula:C20H19ClN4 Package:Package according to customer requirements
Molecular Weight:350.845 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Quality control
PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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