hydroxyzine hydrochloride

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Chemical Information

Product name：hydroxyzine hydrochloride	Purity：99% min
CAS NO：2192-20-3	Solubility：H2O : ≥ 150 mg/mL (334.95 mM)
Molecular Formula：C₂₁H₂₉Cl₃N₂O₂	Package：Package according to customer requirements
Molecular Weight：447.8260	Storage：Store at -20℃

Quality control

Remarks

Hydroxyzine dihydrochloride is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Properties:

Appearance & Physical State: powder
Density: 1.182 g/cm3
Boiling Point: 499.2ºC at 760 mmHg
Melting Point: 190-192ºC
Flash Point: 255.7ºC
Storage Condition: Refrigerator
Vapor Pressure: 8.78E-11mmHg at 25°C

Histamine Receptor Inhibitors Related Products:

Pitolisant; Pitolisant oxalate; Loratadine; Bepotastine; Ciproxifan; Ciproxifan Maleate; Fexofenadine hydrochloride; Azatadine maleate; Betahistine dihydrochloride; Ebastine ; Pitolisant hydrochloride

References

[1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63.

[2]. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84.