SCH29851 Loratadine

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Chemical Information

Product name：SCH29851 Loratadine	Purity：98% min
CAS NO：79794-75-5	Solubility：DMSO : 50 mg/mL (130.59 mM)
Molecular Formula：C₂₂H₂₃ClN₂O₂	Package：Package according to customer requirements
Molecular Weight：382.883	Storage：Store at 2-8ºC

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Remarks

Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies. In structure, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.

Properties:
Appearance & Physical State: White powder
Density: 1.261 g/cm3
Melting Point: 134-136ºC
Boiling Point: 531.3ºCat 760 mmHg
Flash Point: 275.1ºC
Stability: Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.

Histamine Receptor Inhibitors Related Products:

Pitolisant; Pitolisant oxalate; Bepotastine; Ciproxifan; Ciproxifan Maleate; Fexofenadine hydrochloride; Hydroxyzine dihydrochloride; Azatadine maleate; Betahistine dihydrochloride; Ebastine ; Pitolisant hydrochloride

References

[1]. Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50.

[2]. Menardo JL, Horak F, Danzig MR, Czarlewski W. A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4.

[3]. Monroe EW. Loratadine in the treatment of urticaria. Clin Ther. 1997 Mar-Apr;19(2):232-42.