Pitolisant hydrochloride

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Chemical Information

Product name：Pitolisant hydrochloride	Purity：98% min
CAS NO：903576-44-3	Solubility：DMSO : ≥ 43 mg/mL (129.40 mM)
Molecular Formula：C₁₇H₂₇Cl₂NO	Package：Package according to customer requirements
Molecular Weight：332.308	Storage：-20 ℃

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Remarks

Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).

Chemical Name:

1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine,hydrochloride

Synonyms:

Pitolisant hydrochloride;

Ciproxidine;

Piperidine,1-[3-[3-(4-chlorophenyl)propoxy]propyl]-,hydrochloride;

Histamine Receptor Inhibitors Related Products:

Pitolisant; Pitolisant oxalate; Loratadine; Bepotastine; Ciproxifan; Ciproxifan Maleate; Fexofenadine hydrochloride; Hydroxyzine dihydrochloride; Azatadine maleate; Betahistine dihydrochloride; Ebastine

References

[1]. Ligneau X, et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.

[2]. Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by LY170053 in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9.