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PK11007

PK11007  38275-34-2
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Chemical Information
Product name:PK11007 Purity:98% min
CAS NO:38275-34-2 Solubility:Soluble in DMSO
Molecular Formula:C6H5ClN2O4S Package:Package according to customer requirements
Molecular Weight:236.633 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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Remarks
PK11007 is a mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53. It effectively kills cancer cells, especially with null or mutant p53 background, and shows only low cytotoxicity toward normal cells. PK11007 acts by two routes: p53 dependent and p53 independent. PK11007 stabilized p53 in vitro via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. Unstable p53 was reactivated by PK11007 in some cancer cell lines, leading to up-regulation of p53 target genes such as p21 and PUMA. PK11007 induces mainly caspase-independent cell death.

 

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