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Serdemetan (JNJ-26854165)

Serdemetan (JNJ-26854165) 881202-45-5
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Chemical Information
Product name:Serdemetan (JNJ-26854165) Purity:98% min
CAS NO:881202-45-5 Solubility:DMSO : 50 mg/mL (152.25 mM)
Molecular Formula:C21H20N4 Package:Package according to customer requirements
Molecular Weight:328.410 Storage:Store at -20℃
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Remarks

Serdemetan, also known as JNJ-26854165, is an orally bioavailable, small-molecule HDM2 antagonist with potential antineoplastic activity. HDM2 antagonist JNJ-26854165 inhibits the binding of the HDM2–p53 complex to the proteasome, blocking the degradation of p53; p53 signaling and p53-mediated induction of tumor cell apoptosis may thus be restored. In addition to p53, degradation of other HDM2 client proteins may be inhibited.

 

 

 

E3 Ligase Inhibitors Related Products:

Lenalidomide; Pomalidomide; Serdemetan; TAME; RITA; Apcin; GMB-475; Avadomide; BC-1258

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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