BC-1215 is an inhibitor of F-box protein 3 (Fbxo3, a ubiquitin E3 ligase component) with IC50 of 0.9 μg/mL and LC50 of 87 μg/ml for IL-1β release. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1-6.
Synonyms:
N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine;
N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine;
1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-
E3 Ligase Inhibitors Related Products:
Lenalidomide; Pomalidomide; Serdemetan; TAME; RITA; Apcin; GMB-475; Avadomide