Apcin

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Chemical Information

Product name：Apcin	Purity：98% min
CAS NO：300815-04-7	Solubility：DMSO : 125 mg/mL (284.97 mM)
Molecular Formula：C₁₃H₁₄Cl₃N₇O₄	Package：Package according to customer requirements
Molecular Weight：438.654	Storage：-20℃

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Remarks

Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis.

CDK Inhibitors Related Products:

Palbociclib HCl; SNS-032; PF-00562271 Besylate; A-674563; NU6027; 1-NM-PP1; Trilaciclib; YKL-5-124; OTS964 HCl; Indisulam; Palbociclib

References

[1]. Katharine L Sackton, et al. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 2014 Oct 30;514(7524):646-9.

[2]. Katherine V Richeson, et al. Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20. Nat Chem Biol. 2020 May;16(5):546-555.