Palbociclib (PD-0332991) HCl

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Chemical Information

Product name：Palbociclib (PD-0332991) HCl	Purity：98% min
CAS NO：827022-32-2	Solubility：DMSO: 6 mg/mL
Molecular Formula：C₂₄H₂₉N₇O₂	Package：Packaging according to customer requirements
Molecular Weight：483.99	Storage：Store at -20℃

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Remarks

Palbociclib, also known as PD0332991, is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations.

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.

Related Products:

Palbociclib; SNS-032; PF-00562271 Besylate; A-674563; NU6027; 1-NM-PP1; Trilaciclib; YKL-5-124; OTS964 HCl; Indisulam; Apcin

References

[1]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

[2]. Katsumi Y, et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun, 2011, 413(1), 62-68.

[3]. Hsieh FS, et al. Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner. Mol Oncol. 2017 Aug;11(8):1035-1049.