A-674563

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Chemical Information

Product name：A-674563	Purity：98% min
CAS NO：552325-73-2	Solubility：DMSO : 83.33 mg/mL (232.48 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₂₂H₂₂N₄O	Package：Package according to customer requirements
Molecular Weight：358.436	Storage：Store at -20℃

Quality control

Remarks

A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.

CDK Inhibitors Related Products:

Palbociclib HCl; SNS-032; PF-00562271 Besylate; NU6027; 1-NM-PP1; Trilaciclib; YKL-5-124; OTS964 HCl; Indisulam; Apcin; Palbociclib

References

[1]. Luo Y, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther, 2005, 4(6), 977-986.

[2]. Zhu QS, et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res, 2008, 68(8), 2895-2903.

[3]. Zou Y, et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477(1):1-8.