NU6027

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：NU6027	Purity：98% min
CAS NO：220036-08-8	Solubility：DMSO:50 mg/mL (198.98 mM)
Molecular Formula：C₁₁H₁₇N₅O₂	Package：Package according to customer requirements.
Molecular Weight：251.285	Storage：-20ºC

Quality control

COA

Remarks

NU6027 is a potent cyclin-dependent kinase (CDK) and Rad3-related kinase (ATR) inhibitor. NU6027 has been shown to inhibit tumor cell growth. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors

Properties:

Density: 1.53g/cm3

Boiling Point: 549.2ºC at 760 mmHg

Flash Point: 286ºC

Refractive Index: 1.698

Vapor Pressure: 4.1E-12mmHg at 25°C

CDK Inhibitors Related Products:

Palbociclib HCl; SNS-032; PF-00562271 Besylate; A-674563; 1-NM-PP1; Trilaciclib; YKL-5-124; OTS964 HCl; Indisulam; Apcin; Palbociclib

References

[1]. Arris CE, et, al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem. 2000 Jul 27; 43(15): 2797-804.

[2]. Peasland A, et, al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer. 2011 Jul 26;105(3):372-81.